Combination therapy dose-escalation with low-dose cytarabine Ara-C in myelodysplastic syndrome MDS patients who failed hypomethylating agents shows promising activity; expansion cohort enrolling. ALRNthe clinical-stage leader in the field of stabilized, cell-permeating peptides Borsen stiger svagt 2 treat cancer and other diseases, announced today the presentation of two posters at the 60th Annual American Society of Hematology ASH Meeting:.
For strategic reasons, Aileron has decided not to take the PTCL indication forward into a pivotal trial. Due to these data, Aileron has already begun dosing an expansion cohort of MDS patients who have failed hypomethylating agents with this combination and expects to report interim results in the first half of Two different dosing regimens,
Borsen stiger svagt 2 weekly and three-times per week, were tested and no responses were seen when administering ALRN once weekly.
Dose escalation in the three-times per week dosing arm continues. For more detail on these planned trials, please view our corporate presentation at:. ALRN is a first-in-class, stabilized cell-permeating alpha-helical peptide Borsen stiger svagt 2 mimics the p53 tumor suppressor protein to disrupt its interactions with both its endogenous inhibitors, MDMX and MDM2. For p53 wild-type tumors, ALRN can restore tumor suppression.
Aileron is a clinical-stage biopharmaceutical company advancing a proprietary platform of cell-permeating alpha-helical peptides that address the most important intracellular targets in oncology and other therapeutic areas.
The stabilized helical structure of our peptides allows the design of cell-permeating therapeutic agents with large molecular surfaces for optimal target binding properties, resulting in unique drugs like ALRN Our current focus is to improve the standard of care for patients with solid tumors and hematological malignancies by developing safe and effective therapies that leverage our proprietary peptide platform.
Statements in this press release about Aileron's future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of Any forward-looking statements contained in this press release speak only as of the date hereof, and Aileron specifically disclaims any obligation to update any forward-looking statement, whether because of new information, future events or otherwise.
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